David Baker has used 1.5 million GPU hours on NERSC systems and published at least eight major papers acknowledging NERSC. - Credit: UW Medicine
David Baker, a computational biologist and professor of biochemistry, Howard Hughes Medical Institute investigator, director of the Institute for Protein Design at the University of Washington, and prolific user of the systems at the National Energy Research Scientific Computing Center (NERSC), has been awarded a Nobel Prize for Chemistry for his work in computational protein design.
Baker’s body of work centers around using computational approaches to design entirely new proteins that may solve global challenges in fields like medicine, technology, and sustainability – innovations like novel vaccines and antivirals, ways of breaking down plastics in the environment, and artificial photosynthesis. He and his team developed Rosetta, an algorithm for ab initio protein structure prediction; it has since been expanded into AI-powered tools like RoseTTAfold, which uses a three-track neural network to quickly and accurately predict protein structures based on limited information.
According to the Royal Swedish Academy, which awards the Nobel Prize, “Proteins generally consist of 20 different amino acids, which can be described as life’s building blocks. In 2003, David Baker succeeded in using these blocks to design a new protein that was unlike any other protein. Since then, his research group has produced one imaginative protein creation after another, including proteins that can be used as pharmaceuticals, vaccines, nanomaterials, and tiny sensors.”
Since first accessing NERSC systems in 2021, Baker’s team has used 1.5 million GPU hours on NERSC’s Perlmutter system and published at least eight major papers acknowledging NERSC, on topics ranging from modeling protein-protein interactions that are key to biological processes to illuminating microbial “dark matter” through metagenomics. Baker and his team were among the first to use Perlmutter’s GPUs when they were installed in 2021. In June 2024, Baker described his work and the ways in which NERSC has enabled it in a seminar, part of the NERSC@50 seminar series celebrating NERSC’s 50th anniversary.
About NERSC and Berkeley Lab
The National Energy Research Scientific Computing Center (NERSC) is the mission computing facility for the U.S. Department of Energy Office of Science, the nation’s single largest supporter of basic research in the physical sciences.
Located at Lawrence Berkeley National Laboratory (Berkeley Lab), NERSC serves 11,000 scientists at national laboratories and universities researching a wide range of problems in climate, fusion energy, materials sciences, physics, chemistry, computational biology, and other disciplines. An average of 2,000 peer-reviewed science results a year rely on NERSC resources and expertise, which has also supported the work of six Nobel prize-winning individuals and teams.
NERSC is a U.S. Department of Energy Office of Science User Facility.